Characterization of pre-insertion loci of de novo L1 insertions
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چکیده
منابع مشابه
L1 Hybridization Enrichment: A Method for Directly Accessing De Novo L1 Insertions in the Human Germline
Long interspersed nuclear element 1 (L1) retrotransposons are the only autonomously mobile human transposable elements. L1 retrotransposition has shaped our genome via insertional mutagenesis, sequence transduction, pseudogene formation, and ectopic recombination. However, L1 germline retrotransposition dynamics are poorly understood because de novo insertions occur very rarely: the frequency o...
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ژورنال
عنوان ژورنال: Gene
سال: 2007
ISSN: 0378-1119
DOI: 10.1016/j.gene.2006.08.024